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Jump to Jump to search Naked cuticle Nkd is a conserved family of intracellular proteins encoded in most animal genomes. Wieschaus and colleagues in their genetic screens for pattern-formation mutants in the fruit fly Drosophila melanogaster. Like many cleverly named fly mutants, the name "naked cuticle" derives from the fact that mutants lack most of the hair-like protrusions from their ventral cuticle and thus appear "naked". Nkd was linked to Wnt aling based on expansion of Wnt aling in nkd mutants, by overexpression of Nkd mimicking loss of Wnt aling, [2] and by the binding of Nkd protein to the Wnt al transducing protein Dishevelled Dsh. Vertebrate and invertebrate Nkd proteins have additional regions of homology that presumably mediate specific protein functions.

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Wieschaus and colleagues in their genetic screens for pattern-formation mutants in the fruit fly Drosophila melanogaster. Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster.

Vertebrate and invertebrate Nkd proteins have additional regions of homology that presumably mediate specific protein functions. Zygotic loci on the third chromosome. Mice with a mutant Nkd1 protein had a mild sperm maturation defect, [13] but mice lacking both Nkd1 tgt Nkd2 were viable without obvious sperm defects.

Naked cuticle targets dishevelled to antagonize Wnt al transduction. Like many cleverly named fly mutants, the name "naked cuticle" derives from the fact that mutants lack most of the hair-like protrusions from their ventral cuticle and thus appear "naked". Nkd was linked to Wnt aling based on expansion of Wnt aling in nkd mutants, by overexpression of Nkd mimicking loss of Wnt aling, [2] and by the binding of Nkd protein to the Wnt al transducing protein Dishevelled Dsh.

Genes Dev. Jump to Jump to search Naked cuticle Nkd is a conserved family of intracellular proteins encoded in most animal genomes. Nkd3 escortss zebrafish [12].

For example, Nkd2 but not Nkd1 associates with the secreted EGF -family ligand TGF alpha via a sequence between the third and fourth block that is only in Nkd2, [6] and a sequence between the third and fourth block that is highly conserved in Drosophila species but is neither present in the more distantly related mosquito Anopheles gambiae Nkd nor in any known vertebrate Nkds mediates nuclear import via binding to the nuclear import factor importin -alpha3.

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